Aside from getting feet to look right, drawing hands is the most difficult thing to learn for the anatomy buff.
This is the same for building a 3D character. Getting the loops right and trying to make sure they don’t spill over into the rest of the body can be a major challenge, so I have added a quick demo here.
Please note this is not the only way to resolve the loops of the hands (I’m sure I’ve done better myself), but this is how this particular hand turned out.